First access the "Email Accounts" section of CPanel

Once there, locate the email account you wish to set up the client for and click on "Setup Mail Client"
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This will give you several automatic configuration options for many popular email clients
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You can also choose to do Manual Configuration down the page
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It is highly recommended to use the Secure SSL/TLS connection option to secure your e-mail delivery and sending

You may want to read our article on setting up Free SSL for your Hosting.